Pathologies of Cognition

ImageAfternoon presentation focuses on pathologies of cognition with Dr. Anjan Chatterjee. Session opened with definitions for dementia and Alzheimer disease. One indicator is patient/relative ratio rule of thumb (when patient concerned but not relative then depression, when relative concerned but not patient, Alzheimer). Still the overall these areas are provide one of the most emotional social issues today. Dementia is a major problem: 10% of people over the age of 65 or 5.1 million cases in the United States with 16 million expected by 2040. Currently dementia costs 148 billion/year caring for patients with dementia. It is important to remember that age is a major risk factor

–65-69  –  2%
–70-74  –  4%
–74-79  –  8%
–80-85  –  16%
–over 85  –  40%
•Over 85 – (with this age group the fastest growing segment of the population)
Alzheimer entails loss of cognition (repeating oneself within an hour) decrease in activities of daily living (caring for oneself) and personality changes. The neurological reasoning entails two phenomenon: Amyloid Plaques and Neurofibrillary Tangles (disagreement over which most important)Image
•Amyloid Plaques (Ab) includes the extracellular accumulation of Ab  (fragment of the amyloid precursor protein). Abnormal processing of APP critical to pathophysiology of Alzheimer’s disease.
•Neurofibrillary Tangles define Intracellular, paired helical structures composed of hyperphosphorylated tau. The tangles correlate well with disease severity and neuronal death.
The reason “why” these occur and contribute to Alzheimer remains unknown but their overall impact result in brain shrinkage over time.

About Dean G. Blevins

Dr. Dean G. Blevins currently serves as Professor of Practical Theology and Christian Discipleship at Nazarene Theological Seminary. An ordained elder, Dean has ministered in diverse settings and currently also serves at the USA Regional Education Coordinator for the Church of the Nazarene. A prolific author, Dr. Blevins recently co-wrote the textbook Discovering Discipleship and edits Didache: Faithful Teaching, a journal for Wesleyan Education.
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